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Cellosaurus ND32945 (CVCL_EY37)

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Cell line name ND32945
Synonyms FTDP-17-1
Accession CVCL_EY37
Resource Identification Initiative To cite this cell line use: ND32945 (RRID:CVCL_EY37)
Comments Population: Caucasian.
Donor information: At sampling donor was not affected with frontotemporal dementia but at risk for disease.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:6893; MAPT; Simple; p.Asn279Lys (c.837T>G) (N596K, c.1788T>G or N614K, c.1842T>G); ClinVar=VCV000014253; Zygosity=Unspecified (PubMed=22952635).
Disease Frontotemporal dementia-1 (NCIt: C217087)
Behavioral variant of frontotemporal dementia (ORDO: Orphanet_275864)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A9R2 (FTDP-17-1-I)CVCL_A9R3 (FTDP-17-1-II)
Sex of cell Male
Age at sampling 43Y
Category Finite cell line
Publications

PubMed=22952635; DOI=10.1371/journal.pone.0043099; PMCID=PMC3428297
Selina Wray, Matthew Self, Patrick A. Lewis, Jan-Willem Taanman, Natalie S. Ryan, Colin J. Mahoney, Yu-Ying Liang, Michael J. Devine, Una-Marie Sheerin, Henry Houlden, Huw R. Morris ...Show all 46 authors... , Daniel Healy, Jose-Felix Marti-Masso, Elisavet Preza, Suzanne Barker, Margaret Sutherland, Roderick A. Corriveau, Michael D'Andrea, Anthony Henry Vernon Schapira, Ryan J. Uitti, Mark Guttman, Grzegorz Opala, Barbara Jasinska-Myga, Andreas Puschmann, Christer Nilsson, Alberto J. Espay, Jaroslaw Slawek, Ludwig Gutmann, Bradley F. Boeve, Kevin Boylan, Alexander Jon Stoessl, Owen A. Ross, Nicholas John Maragakis, Jay Arthur Van Gerpen, Melissa Gerstenhaber, Katrina Ann Gwinn-Hardy, Ted Murray Dawson, Ole Isacson, Karen S. Marder, Lorraine N. Clark, Serge E. Przedborski, Steven Finkbeiner, Jeffrey D. Rothstein, Zbigniew Kudzin Wszolek, Martin Neil Rossor, John Hardy; Show fewer authors
NINDS ALS iPSC Consortium
NINDS Huntington's Disease iPSC Consortium
NINDS Parkinson's Disease iPSC Consortium
Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.
PLoS ONE 7:e43099.1-e43099.8(2012)

PubMed=26143746; DOI=10.1016/j.stemcr.2015.06.001; PMCID=PMC4618448
Marc Ehrlich, Anna-Lena Hallmann, Peter Reinhardt, Marcos J. Arauzo-Bravo, Sabrina Korr, Albrecht Ropke, Olympia Ekaterini Psathaki, Petra Ehling, Sven Gunther Meuth, Adrian L. Oblak, Jill R. Murrell ...Show all 17 authors... , Bernardino Ghetti, Holm Zaehres, Hans Robert Scholer, Jared Sterneckert, Tanja Kuhlmann, Gunnar Hargus; Show fewer authors
Distinct neurodegenerative changes in an induced pluripotent stem cell model of frontotemporal dementia linked to mutant Tau protein.
Stem Cell Reports 5:83-96(2015)

Cross-references
Cell line collections (Providers) Coriell; ND32945 - Discontinued
NHCDR; ND32945
Encyclopedic resources Wikidata; Q54929620
Entry history
Entry creation26-Sep-2016
Last entry update14-Aug-2025
Version number16