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Cellosaurus HCC827-PR (CVCL_EQ68)

[Text version]
Cell line name HCC827-PR
Synonyms HCC827 PR
Accession CVCL_EQ68
Resource Identification Initiative To cite this cell line use: HCC827-PR (RRID:CVCL_EQ68)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:9588; PTEN.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=17560336; DOI=10.1016/j.ccr.2007.04.021
Igor Vivanco, Nicolaos Palaskas, Chris Tran, Stephen P. Finn, Gad Getz, Norman J. Kennedy, Jing Jiao, Joshua Rose, Wan-Ling Xie, Massimo Loda, Todd Robert Golub ...Show all 15 authors... , Ingo K. Mellinghoff, Roger John Davis, Hong Wu, Charles Lazelle Sawyers; Show fewer authors
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.
Cancer Cell 11:555-569(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EQ68
Encyclopedic resources Wikidata; Q54881804
Gene expression databases GEO; GSM183438
GEO; GSM183439
Entry history
Entry creation26-Sep-2016
Last entry update10-Apr-2025
Version number14