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Cellosaurus 2LMP (CVCL_EQ20)

[Text version]
Cell line name 2LMP
Synonyms 2-LMP
Accession CVCL_EQ20
Resource Identification Initiative To cite this cell line use: 2LMP (RRID:CVCL_EQ20)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=9739048; DOI=10.1172/JCI3492
Zhai Y.-F., Guo R.-B., Hsu T.-L., Yu G.-L., Ni J., Kwon B.S., Jiang G.-W., Lu J., Tan J., Ugustus M., Carter K., Rojas L., Zhu F., Lincoln C., Endress G., Xing L., Wang S., Oh K.-O., Gentz R., Ruben S.M., Lippman M.E., Hsieh S.-L., Yang D.-J.
LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.
J. Clin. Invest. 102:1142-1151(1998)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EQ20
Encyclopedic resources Wikidata; Q54584606
Gene expression databases GEO; GSM1401670
Entry history
Entry creation26-Sep-2016
Last entry update05-Oct-2023
Version number16