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Cellosaurus (CVCL_EL61)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: JFCR39 cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Population: Caucasian.
Doubling time: 24 hours (PubMed=7718330); 25 hours (PubMed=25984343); 26.1 hours (NCI-DCTD=OVCAR-8); 31.93 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; Fluorescent probe library screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Misspelling: OVACAR8; Cosmic=1526923.
Misspelling: OVOCAR-8; Note=Occasionally.
Misspelling: OVOCAR8; Note=Occasionally.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gln26Arg (c.77A>G); Zygosity=Heterozygous (PubMed=28273451; Cosmic-CLP=905991).
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Gly776Val (c.2327G>T); ClinVar=VCV000163410; Zygosity=Heterozygous (PubMed=17088437).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Pro121His (c.362C>A); Zygosity=Heterozygous (PubMed=28273451; Cosmic-CLP=905991).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=9331090; PubMed=20204287; PubMed=21912889; PubMed=28273451; Cosmic-CLP=905991).
HLA typing Source: PubMed=15748285
Class I
HLA-AA*01:01:01,25:01
HLA-BB*57:01:01
HLA-CC*06:02
Class II
HLA-DPDPB1*02:01:02,13:01
HLA-DQDQB1*03:03:02,06:02
HLA-DRDRB1*07:01,15:01:01

Source: PubMed=26589293
Class I
HLA-AA*01:01,25:01
HLA-BB*57:01,57:01
HLA-CC*06:02,06:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.22
Native American0
East Asian, North3.41
East Asian, South0
South Asian0.98
European, North60.74
European, South34.66
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=905991; DOI=10.4172/2157-7145.S2-005; PubMed=19372543; PubMed=25877200; PubMed=30485824; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO11
D1S165619.3
D2S44110,11
D2S133819,23
D3S135816,18
D5S81812
D7S82012
D8S117910
D10S124814
D12S39115,18
D13S31712
D16S53913
D18S5114
D19S43314,16
D21S1128
D22S104511
FGA20
Penta D12
Penta E10
TH017
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=25
Publications






cells.
Invest. Urol. 14:335-343(1977)


Tullio Giraldi;
Effects of dimethyltriazenes on in vitro Lewis lung carcinoma tumor lines with different metastatic capacity.
Invasion Metastasis 4:179-188(1984)



PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites.
Mol. Biochem. Parasitol. 67:59-68(1994)


Edwin W. Ades, Barbara Ferris, Ralph L. Nachman, Kathryn L. Kellar;
BMEC-1: a human bone marrow microvascular endothelial cell line with primary cell characteristics.
Microvasc. Res. 52:221-234(1996)




Cancer Chemother. Pharmacol. 43:198-204(1999)



immune-compromised patients.
Jpn. J. Cancer Res. 92:83-87(2001)


Susan Band Horwitz;
Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.
Mol. Cancer Ther. 1:3-10(2001)


Kohzaburo Fujikawa-Yamamoto, Hiroko Yamagishi, Minoru Miyagoshi;
Octaploid Meth-A cells are established from a highly polyploidized cell population.
Cell Prolif. 36:87-100(2003)




Gynecol. Oncol. 92:15-21(2004)


Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William C. Reinhold, John N. Weinstein, Michael Rudolf Stratton, P. Andrew Futreal, Richard Wooster;
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)



VWF-platelet interactions.
J. Thromb. Haemost. 5:1963-1970(2007)



Establishment and characterization of a human adenoid cystic carcinoma cell line forming colonies cultured in collagen gel and transplantable in nude mice.
Oncol. Rep. 17:335-340(2007)




Nat. Biotechnol. 26:1269-1275(2008)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Alex Chang, Mousumi Dhara, Li-Fu Wang, Felix Ruckert, Robert Grutzmann, Christian Pilarsky, Kamel Izeradjene, Sunil R. Hingorani, Pearl Huang, Susan E. Davies, William Plunkett ...Show all 19 authors... , Merrill Jon Egorin, Ralph H. Hruban, Nigel Whitebread, Karen McGovern, Julian Adams, Christine A. Iacobuzio-Donahue, John Griffiths, David Arthur Tuveson; Show fewer authors
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Science 324:1457-1461(2009)



switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)



Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.
Proc. Natl. Acad. Sci. U.S.A. 108:7535-7540(2011)



Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas.
PLoS ONE 6:e27271.1-e27271.12(2011)


Dagmar Wirth, Dirk W. Heinz, Joop van den Heuvel, Konrad Bussow;
Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.
PLoS ONE 6:e27829.1-e27829.8(2011)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Eugenie S. Kleinerman;
Genetically modified T cells targeting interleukin-11 receptor alpha-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases.
Cancer Res. 72:271-281(2012)


Robert M. Bachoo, Alice L. Smith, Michael D. Story, Stan Sidhu, Bruce G. Robinson, Fiemu E. Nwariaku, Adi F. Gazdar, Richard J. Auchus, Jerry W. Shay;
Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor.
PLoS ONE 8:e65624.1-e65624.8(2013)


Hisato Kawakami, Isamu Okamoto, Kyoichi Terao, Kazuko Sakai, Minoru Suzuki, Shinya Ueda, Kaoru Tanaka, Kiyoko Kuwata, Yume Morita, Koji Ono, Kazuto Nishio ...Show all 14 authors... , Yasumasa Nishimura, Katsumi Doi, Kazuhiko Nakagawa; Show fewer authors
Human papillomavirus DNA and p16 expression in Japanese patients with oropharyngeal squamous cell carcinoma.
Cancer Med. 2:933-941(2013)


Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)


Xin Li, Pei-Wu Li, Qi Zhang, Ran Li, Wen Zhang, Xiao-Xia Ding, Jia-Wen Lei, Zhao-Wei Zhang;
Development and application of an immunoaffinity column enzyme immunoassay for mycotoxin zearalenone in complicated samples.
PLoS ONE 9:e85606.1-e85606.7(2014)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)


Gabriela Kalna, Karen Blyth, Douglas Strathdee, Eyal Gottlieb;
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Nat. Cell Biol. 17:1317-1326(2015)


Chris P. Miller, Kelsey M. Haas, Hanna Y. Irie, Su-In Lee, C. Anthony Blau, Judit Villen;
The proteomic landscape of triple-negative breast cancer.
Cell Rep. 11:630-644(2015)


Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson ...Show all 28 authors... , Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)



Identifies HOPX as a regulator of primitive hematopoiesis.
Cell Rep. 20:1597-1608(2017)



literature.
Cancer Res. 77:2784-2788(2017)


Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A. Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal J. Patel ...Show all 27 authors... , Alistair White, Sharad R. Patel, Laura Clarke, Reena Halai, Christopher Michael Kirton, Anja Kolb-Kokocinski, Philip L. Beales, Ewan Birney, Davide Danovi, Angus Iain Lamond, Willem Hendrik Ouwehand, Ludovic Vallier, Fiona Mary Watt, Richard Michael Durbin, Oliver Stegle, Daniel J. Gaffney; Show fewer authors
Common genetic variation drives molecular heterogeneity in human iPSCs.
Nature 546:370-375(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)


Isidre Ferrer, Adolfo Lopez de Munain, Angel Raya, Joaquin Castilla, Rosario Sanchez-Pernaute, Jose Antonio del Rio;
iPS cell cultures from a Gerstmann-Straussler-Scheinker patient with the Y218N PRNP mutation recapitulate Tau pathology.
Mol. Neurobiol. 55:3033-3048(2018)




Cancer Cell 33:386-400.e5(2018)



lymphoblastic leukemia.
Cancer Res. 79:2339-2351(2019)


Katsushi Tokunaga, Masao Nagasaki, Seiji Kito, Keiichi Isoyama, Masafumi Onodera, Hideo Kaneko, Naomichi Matsumoto, Fumihiko Matsuda, Keitaro Matsuo, Yoshiyuki Takahashi, Tomoji Mashimo ...Show all 13 authors... , Seiji Kojima, Tomoo Ogi; Show fewer authors
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
Sci. Adv. 6:eabd7197.1-eabd7197.15(2020)


Mariana Martins, Ana Maria Cardoso, Maria Rosario Almeida, Maria do Carmo Macario, Isabel Santana, Joao Peca, Ana Luisa Cardoso;
Generation and characterization of novel iPSC lines from a Portuguese family bearing heterozygous and homozygous GRN mutations.
Biomedicines 10:1905.1-1905.17(2022)



magnetically controlled carbon nanotubes.
Sci. Adv. 9:eade5321.1-eade5321.14(2023)

Entry history
Entry creation04-Apr-2012
Last entry update25-Jun-2026
Version number50