Cellosaurus cell line UCSD239i-APP2-1 (CVCL

Cellosaurus UCSD239i-APP2-1 (CVCL_EJ99)

Cross-references
Cell line name	UCSD239i-APP2-1
Synonyms	APPDp2.1; Appdp2.1; APPdp2.1
Accession	CVCL_EJ99
Resource Identification Initiative	To cite this cell line use: UCSD239i-APP2-1 (RRID:CVCL_EJ99)
Comments	Population: Caucasian; Finnish. Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Disease	Alzheimer's disease 1 (NCIt: C146894) Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_EK00 ! UCSD240i-APP2-2 CVCL_1N92 ! UCSD241i-APP2-3
Sex of cell	Female
Age at sampling	60Y
Category	Induced pluripotent stem cell
Publications	PubMed=22278060; DOI=10.1038/nature10821; PMCID=PMC3338985 Mason A. Israel, Shauna H. Yuan, Cedric Bardy, Sol M. Reyna, Yang-Ling Mu, Cheryl M. Herrera, Michael P. Hefferan, Sebastiaan F.J. Van Gorp, Kristopher L. Nazor, Francesca Sesillo Boscolo, Christian T. Carson, Louise C. Laurent, Martin Marsala ...Show all 17 authors... , Fred Harrison Gage, Anne M. Remes, Edward H. Koo, Lawrence Steven B. Goldstein; Show fewer authors Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 482:216-220(2012) PubMed=30686764; DOI=10.1016/j.stem.2018.12.013; PMCID=PMC6414424 Rik van der Kant, Vanessa F. Langness, Cheryl M. Herrera, Daniel A. Williams, Lauren K. Fong, Yves Leestemaker, Evelyne Steenvoorden, Kevin D. Rynearson, Jos F. Brouwers, J. Bernd Helms, Huib Ovaa, Martin Giera, Steven L. Wagner ...Show all 15 authors... , Anne G. Bang, Lawrence Steven B. Goldstein; Show fewer authors Cholesterol metabolism is a druggable axis that independently regulates Tau and amyloid-beta in iPSC-derived Alzheimer's disease neurons. Cell Stem Cell 24:363-375.e9(2019)
Cell line collections (Providers)	WiCell; ucsd239i-app2-1 - Discontinued
Cell line databases/resources	SKIP; SKIP005445
Encyclopedic resources	Wikidata; Q54990046
Entry history
Entry creation	26-Sep-2016
Last entry update	14-Aug-2025
Version number	14