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Cellosaurus HCC827 ER3 (CVCL_EJ09)

[Text version]
Cell line name HCC827 ER3
Synonyms ER3
Accession CVCL_EJ09
Resource Identification Initiative To cite this cell line use: HCC827 ER3 (RRID:CVCL_EJ09)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line

PubMed=22751098; DOI=10.1038/ng.2330
Zhang Z.-F., Lee J.C., Lin L.-P., Olivas V., Au V., LaFramboise T., Abdel-Rahman M., Wang X.-Q., Levine A.D., Rho J.K., Choi Y.J., Choi C.-M., Kim S.-W., Jang S.J., Park Y.S., Kim W.S., Lee D.H., Lee J.-S., Miller V.A., Arcila M.E., Ladanyi M., Moonsamy P., Sawyers C.L., Boggon T.J., Ma P.C., Costa C., Taron M., Rosell R., Halmos B., Bivona T.G.
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
Nat. Genet. 44:852-860(2012)

Cell line databases/resources cancercelllines; CVCL_EJ09
Encyclopedic resources Wikidata; Q54881785
Gene expression databases GEO; GSM938758
GEO; GSM938759
GEO; GSM938760
GEO; GSM938761
GEO; GSM938762
GEO; GSM938763
Polymorphism and mutation databases Cosmic; 1716794
Entry history
Entry creation26-Sep-2016
Last entry update05-Oct-2023
Version number12