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Cellosaurus HCC827 ER1 (CVCL_EJ07)

[Text version]
Cell line name HCC827 ER1
Synonyms HCC827-ER1; HCC 827 ER1; ER1
Accession CVCL_EJ07
Resource Identification Initiative To cite this cell line use: HCC827 ER1 (RRID:CVCL_EJ07)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=22751098; DOI=10.1038/ng.2330; PMCID=PMC3408577
Zhen-Feng Zhang, Jae Cheol Lee, Lu-Ping Lin, Victor Olivas, Valerie Au, Thomas LaFramboise, Mohamed Abdel-Rahman, Xiao-Qi Wang, Alan D. Levine, Jin Kyung Rho, Yun Jung Choi ...Show all 30 authors... , Chang-Min Choi, Sang-We Kim, Se Jin Jang, Young Soo Park, Woo Sung Kim, Dae Ho Lee, Jung-Shin Lee, Vincent A. Miller, Maria E. Arcila, Marc Ladanyi, Philicia Moonsamy, Charles Lazelle Sawyers, Titus J. Boggon, Patrick C. Ma, Carlotta Costa, Miquel Taron, Rafael Rosell, Balazs Halmos, Trever Grant Bivona; Show fewer authors
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
Nat. Genet. 44:852-860(2012)

PubMed=32928921; DOI=10.1158/0008-5472.CAN-20-1634; PMCID=PMC11106563
Yu-Ting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco ...Show all 45 authors... , Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ning-Ping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yong-Ying Jiang, Zhi-Jun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiao-Yan Ma, Pijus K. Mandal, Timothy J. McAfoos, Meredith A. Miller, Robert A. Mullinax, Michael Peoples, Vandhana Ramamoorthy, Sahil Seth, Nakia D. Spencer, Erika Suzuki, Christopher C. Williams, Simon S. Yu, Andy M. Zuniga, Giulio F. Draetta, Joseph R. Marszalek, Timothy P. Heffernan, Nancy E. Kohl, Philip Jones; Show fewer authors
Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and EGFR-independent resistance mechanisms toward osimertinib.
Cancer Res. 80:4840-4853(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EJ07
Encyclopedic resources Wikidata; Q54881783
Gene expression databases GEO; GSM935084
Polymorphism and mutation databases Cosmic; 1716792
Entry history
Entry creation26-Sep-2016
Last entry update10-Apr-2025
Version number14