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Cellosaurus HCC827 ER1 (CVCL_EJ07)

[Text version]
Cell line name HCC827 ER1
Synonyms HCC827-ER1; HCC 827 ER1; ER1
Accession CVCL_EJ07
Resource Identification Initiative To cite this cell line use: HCC827 ER1 (RRID:CVCL_EJ07)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line

PubMed=22751098; DOI=10.1038/ng.2330
Zhang Z.-F., Lee J.C., Lin L.-P., Olivas V., Au V., LaFramboise T., Abdel-Rahman M., Wang X.-Q., Levine A.D., Rho J.K., Choi Y.J., Choi C.-M., Kim S.-W., Jang S.J., Park Y.S., Kim W.S., Lee D.H., Lee J.-S., Miller V.A., Arcila M.E., Ladanyi M., Moonsamy P., Sawyers C.L., Boggon T.J., Ma P.C., Costa C., Taron M., Rosell R., Halmos B., Bivona T.G.
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
Nat. Genet. 44:852-860(2012)

PubMed=32928921; DOI=10.1158/0008-5472.CAN-20-1634
Sun Y.-T., Meyers B.A., Czako B., Leonard P., Mseeh F., Harris A.L., Wu Q., Johnson S., Parker C.A., Cross J.B., Di Francesco M.E., Bivona B.J., Bristow C.A., Burke J.P., Carrillo C.C., Carroll C.L., Chang Q., Feng N.-P., Gao G., Gera S., Giuliani V., Huang J.K., Jiang Y.-Y., Kang Z.-J., Kovacs J.J., Liu C.-Y., Lopez A.M., Ma X.-Y., Mandal P.K., McAfoos T., Miller M.A., Mullinax R.A., Peoples M., Ramamoorthy V., Seth S., Spencer N.D., Suzuki E., Williams C.C., Yu S.S., Zuniga A.M., Draetta G.F., Marszalek J.R., Heffernan T.P., Kohl N.E., Jones P.
Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and EGFR-independent resistance mechanisms toward osimertinib.
Cancer Res. 80:4840-4853(2020)

Cell line databases/resources cancercelllines; CVCL_EJ07
Encyclopedic resources Wikidata; Q54881783
Gene expression databases GEO; GSM935084
Polymorphism and mutation databases Cosmic; 1716792
Entry history
Entry creation26-Sep-2016
Last entry update05-Oct-2023
Version number12