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Cellosaurus DCR10 (CVCL_EI68)

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Cell line name DCR10
Synonyms DCR 10
Accession CVCL_EI68
Resource Identification Initiative To cite this cell line use: DCR10 (RRID:CVCL_EI68)
Comments Population: Caucasian.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Ser492Arg (c.1476C>A); ClinVar=VCV000376341; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=22270724).
Disease Colorectal carcinoma (NCIt: C2955)
Gardner syndrome (NCIt: C6728)
Gardner syndrome (ORDO: Orphanet_79665)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6895 (DiFi)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=22270724; DOI=10.1038/nm.2609
Clara Montagut, Alba Dalmases, Beatriz Bellosillo, Marta Crespo, Silvia Pairet, Mar Iglesias, Marta Salido, Manuel Gallen, Scot A. Marsters, Siao-Ping Tsai, Andre E. Minoche ...Show all 19 authors... , Somasekar Seshagiri, Sergi Serrano, Heinz Himmelbauer, Joaquim Bellmunt, Ana Rovira, Jeffrey Settleman, Francesc Bosch, Joan Albanell; Show fewer authors
Identification of a mutation in the extracellular domain of the epidermal growth factor receptor conferring cetuximab resistance in colorectal cancer.
Nat. Med. 18:221-223(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI68
ColonAtlas; DCR10
Encyclopedic resources Wikidata; Q54828678
Polymorphism and mutation databases Cosmic; 1690659
Entry history
Entry creation26-Sep-2016
Last entry update19-Dec-2024
Version number14