Cellosaurus logo
expasy logo

Cellosaurus K-562 VPS13A/VPS13C DKO clone 1 (CVCL_E9XV)

[Text][XML][JSON]
Cell line name K-562 VPS13A/VPS13C DKO clone 1
Synonyms K562 VPS13A/VPS13C DKO clone#1
Accession CVCL_E9XV
Resource Identification Initiative To cite this cell line use: K-562 VPS13A/VPS13C DKO clone 1 (RRID:CVCL_E9XV)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:1908; VPS13A.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:23594; VPS13C.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=40463036; DOI=10.1101/2025.05.09.653147; PMCID=PMC12132566
Peng Xu, Rubia Isler Mancuso, Marianna Leonzino, Caroline J. Zeiss, Diane S. Krause, Pietro De Camilli;
Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice.
bioRxiv 2025:05.09.653147-05.09.653147(2025)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1