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Cellosaurus BroLi (CVCL_E997)

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Cell line name BroLi
Accession CVCL_E997
Resource Identification Initiative To cite this cell line use: BroLi (RRID:CVCL_E997)
Comments Doubling time: 5 days (PubMed=20444890); 4-5 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Proteomics; Quantitative.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135817,18
D5S81810,11
D7S8209,11
D8S117911,17
D13S31710,12
D16S53912,13
D18S5116,19
D21S1127.2,29.2
FGA20,26
Penta D13
Penta E10
TH016,9
TPOX8,11
vWA17

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Publications

PubMed=20444890; DOI=10.1128/JVI.02400-09; PMCID=PMC2898224
Roland Houben, Masahiro Shuda, Rita Weinkam, David Schrama, Hui-Chen Feng, Yuan Chang, Patrick S. Moore, Jurgen C. Becker;
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255; PMCID=PMC3281946
Christian Hafner, Roland Houben, Anne Baeurle, Cathrin Ritter, David Schrama, Michael Landthaler, Jurgen C. Becker;
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:e31255.1-e31255.8(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Roland Houben, Christina Dreher, Sabrina Angermeyer, Andreas Borst, Jochen Sven Utikal, Sebastian Haferkamp, Wiebke K. Peitsch, David Schrama, Sonja Hesbacher;
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793; PMCID=PMC5078066
Sonja Hesbacher, Lisa Pfitzer, Katharina Wiedorfer, Sabrina Angermeyer, Andreas Borst, Sebastian Haferkamp, Claus-Jurgen Scholz, Marion Wobser, David Schrama, Roland Houben;
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=30873613; DOI=10.1002/ijc.32280
David Schrama, Eva-Maria Sarosi, Christian Adam, Cathrin Ritter, Ulrike Kaemmerer, Eva Klopocki, Eva-Maria Konig, Jochen Sven Utikal, Jurgen C. Becker, Roland Houben;
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

PubMed=31889939; DOI=10.1186/s12014-019-9263-z; PMCID=PMC6921584
Ulana Kotowski, Boban M. Erovic, Julia Schnoll, Victoria Stanek, Stefan Janik, Martin Steurer, Goran Mitulovic;
Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.
Clin. Proteomics 16:42.1-42.13(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_E997
Encyclopedic resources Wikidata; Q54798314
Gene expression databases GEO; GSM1904845
Polymorphism and mutation databases Cosmic; 1699818
Progenetix; CVCL_E997
Proteomic databases PRIDE; PXD008181
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number18