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Cellosaurus UISO-MCC-1 (CVCL_E996)

[Text version]
Cell line name UISO-MCC-1
Synonyms UISO-MCC 1; UISO-MCC1; UISO-mcc1; UISO; University of Illinois Surgical Oncology-Merkel Cell Carcinoma-1
Accession CVCL_E996
Resource Identification Initiative To cite this cell line use: UISO-MCC-1 (RRID:CVCL_E996)
Comments Doubling time: 64.8 hours (PubMed=8227544); 1.5 days (PubMed=20444890).
Omics: Phenotyping; Drug screening.
Derived from site: In situ; Thigh, skin; UBERON=UBERON_0004262.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=8227544; DOI=10.1016/0190-9622(93)70236-M
Salve G. Ronan, Albert D. Green, Anne Shilkaitis, Tien-Shew W. Huang, Tapas K. Das Gupta;
Merkel cell carcinoma: in vitro and in vivo characteristics of a new cell line.
J. Am. Acad. Dermatol. 29:715-722(1993)

PubMed=10732753; DOI=10.1054/bjoc.1999.1006; PMCID=PMC2374386
Mireille Van Gele, Mourad Kaghad, Joan Helen Leonard, Nadine Van Roy, Jean M. Naeyaert, Marie-Louise Geerts, Simon Van Belle, Veronique F. Cocquyt, Julia A. Bridge, Raf Sciot, Christiane De Wolf-Peeters ...Show all 14 authors... , Anne De Paepe, Daniel Caput, Frank Speleman; Show fewer authors
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
Br. J. Cancer 82:823-826(2000)

PubMed=12209990; DOI=10.1002/ijc.10591
Mireille Van Gele, Joan Helen Leonard, Nadine Van Roy, Heidi Van Limbergen, Simon Van Belle, Veronique F. Cocquyt, Helen R. Salwen, Anne De Paepe, Frank Speleman;
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
Int. J. Cancer 101:137-145(2002)

PubMed=20444890; DOI=10.1128/JVI.02400-09; PMCID=PMC2898224
Roland Houben, Masahiro Shuda, Rita Weinkam, David Schrama, Hui-Chen Feng, Yuan Chang, Patrick S. Moore, Jurgen C. Becker;
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255; PMCID=PMC3281946
Christian Hafner, Roland Houben, Anne Baeurle, Cathrin Ritter, David Schrama, Michael Landthaler, Jurgen C. Becker;
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:e31255.1-e31255.8(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Roland Houben, Christina Dreher, Sabrina Angermeyer, Andreas Borst, Jochen Sven Utikal, Sebastian Haferkamp, Wiebke K. Peitsch, David Schrama, Sonja Hesbacher;
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

Cross-references
Chemistry resources GDSC; 1299074
PharmacoDB; UISOMCC1_1640_2019
Encyclopedic resources Wikidata; Q54990245
Polymorphism and mutation databases Cosmic; 1693074
Cosmic; 1699814
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number16