Cellosaurus cell line BCWM.2 (CVCL

Cellosaurus BCWM.2 (CVCL_E8TQ)

Entry history
Cell line name	BCWM.2
Synonyms	Bing Center for Waldenstrom's Macroglobulinemia.2
Accession	CVCL_E8TQ
Resource Identification Initiative	To cite this cell line use: BCWM.2 (RRID:CVCL_E8TQ)
Comments	Doubling time: 3 days (PubMed=40254718). Omics: Genomics; Whole exome sequencing. Omics: Genomics; Whole genome sequencing. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Mutation; HGNC; HGNC:6735; LYN; Simple; p.Ile318Asn (c.953>A) (I297N); Zygosity=Heterozygous (PubMed=40254718). Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Ser230Asn (c.689G>A) (S243N); ClinVar=VCV003764990; Zygosity=Heterozygous (PubMed=40254718). Mutation; HGNC; HGNC:11241; SPI1; Simple; p.Gln226Glu (c.676G>C); Zygosity=Heterozygous (PubMed=40254718).
Disease	Waldenstrom macroglobulinemia (NCIt: C80307) Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	66Y
Category	Cancer cell line
Publications	DOI=10.1182/blood-2023-190147 Shi-Rong Liu, Xia Liu, Kara M. Soroko, Alexa G. Canning, Amanda Kofides, Choudhury Fabliha Binte Yusuf, Johany Penailillo, Nicholas Tsakmaklis, Christopher J. Patterson, Ruben D. Carrasco, Zachary Richard Hunter ...Show all 15 authors... , Prafulla C. Gokhale, Shayna Rae Sarosiek, Jorge J. Castillo, Steven Peter Treon; Show fewer authors Establishment of the BCWM.2 cell line as a BTK-inhibitor resistant, BCL2 inhibitor sensitive in vitro and in vivo study model for Waldenstrom's macroglobulinemia. Blood 142 Suppl. 1:6613-6614(2023) PubMed=40254718; DOI=10.1111/bjh.20072 Shi-Rong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M. Soroko, Johany Penailillo, Alexa G. Canning, Yang Cao, Guang Yang, Lian Xu, Nicholas Tsakmaklis ...Show all 22 authors... , Hao Sun, Alberto Guijosa, Maria Luisa Guerrera, Christopher J. Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna Rae Sarosiek, Jorge J. Castillo, John M. Hatcher, Zachary Richard Hunter, Steven Peter Treon; Show fewer authors Development and characterization of the novel MYD88 mutated, 6q deleted BCWM.2 cell line for Waldenstrom macroglobulinaemia. Br. J. Haematol. 206:1604-1614(2025)
Entry creation	14-Aug-2025
Last entry update	14-Aug-2025
Version number	1