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Cellosaurus BCWM.2 (CVCL_E8TQ)

[Text version]
Cell line name BCWM.2
Synonyms Bing Center for Waldenstrom's Macroglobulinemia.2
Accession CVCL_E8TQ
Resource Identification Initiative To cite this cell line use: BCWM.2 (RRID:CVCL_E8TQ)
Comments Doubling time: 3 days (PubMed=40254718).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:6735; LYN; Simple; p.Ile318Asn (c.953>A) (I297N); Zygosity=Heterozygous (PubMed=40254718).
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Ser230Asn (c.689G>A) (S243N); ClinVar=VCV003764990; Zygosity=Heterozygous (PubMed=40254718).
  • Mutation; HGNC; HGNC:11241; SPI1; Simple; p.Gln226Glu (c.676G>C); Zygosity=Heterozygous (PubMed=40254718).
Disease Waldenstrom macroglobulinemia (NCIt: C80307)
Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
Publications

DOI=10.1182/blood-2023-190147
Shi-Rong Liu, Xia Liu, Kara M. Soroko, Alexa G. Canning, Amanda Kofides, Choudhury Fabliha Binte Yusuf, Johany Penailillo, Nicholas Tsakmaklis, Christopher J. Patterson, Ruben D. Carrasco, Zachary Richard Hunter ...Show all 15 authors... , Prafulla C. Gokhale, Shayna Rae Sarosiek, Jorge J. Castillo, Steven Peter Treon; Show fewer authors
Establishment of the BCWM.2 cell line as a BTK-inhibitor resistant, BCL2 inhibitor sensitive in vitro and in vivo study model for Waldenstrom's macroglobulinemia.
Blood 142 Suppl. 1:6613-6614(2023)

PubMed=40254718; DOI=10.1111/bjh.20072
Shi-Rong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M. Soroko, Johany Penailillo, Alexa G. Canning, Yang Cao, Guang Yang, Lian Xu, Nicholas Tsakmaklis ...Show all 22 authors... , Hao Sun, Alberto Guijosa, Maria Luisa Guerrera, Christopher J. Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna Rae Sarosiek, Jorge J. Castillo, John M. Hatcher, Zachary Richard Hunter, Steven Peter Treon; Show fewer authors
Development and characterization of the novel MYD88 mutated, 6q deleted BCWM.2 cell line for Waldenstrom macroglobulinaemia.
Br. J. Haematol. 206:1604-1614(2025)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1