Cellosaurus cell line SHP-77 DLL3 KO clone 2C3 (CVCL

Cross-references
Cell line name	SHP-77 DLL3 KO clone 2C3
Synonyms	SHP77-DLL3-KO-2C3
Accession	CVCL_E8SP
Resource Identification Initiative	To cite this cell line use: SHP-77 DLL3 KO clone 2C3 (RRID:CVCL_E8SP)
Comments	Population: Caucasian. Doubling time: ~85 hours (KYinno=KC-4353). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:2909; DLL3. Derived from site: In situ; Lung, left upper lobe; UBERON=UBERON_0008952.
Sequence variations	Mutation; HGNC; HGNC:76; ABL1; Simple; p.Val1128Glu (c.3383T>A); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:9801; RAC1; Simple; p.Tyr32Cys (c.95A>G); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Trp (c.528C>G); ClinVar=VCV000376572; Zygosity=Homozygous (from parent cell line).
Disease	Lung small cell carcinoma (NCIt: C4917) Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1693 (SHP-77)
Sex of cell	Male
Age at sampling	54Y
Category	Cancer cell line
Cell line collections (Providers)	KYinno; KC-4353
Entry history
Entry creation	14-Aug-2025
Last entry update	14-Aug-2025
Version number	1