Cellosaurus cell line RS4;11 mouse MCL1 (CVCL

Cross-references
Cell line name	RS4;11 mouse MCL1
Synonyms	RS4;11-mouse-MCL1
Accession	CVCL_E8JJ
Resource Identification Initiative	To cite this cell line use: RS4;11 mouse MCL1 (RRID:CVCL_E8JJ)
Comments	Population: Caucasian. Genetic integration: Method=Transduction; Gene=MGI; MGI:101769; Mcl1. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4; Note=In frame (from parent cell line). Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8977; PIK3CD; Simple; p.Gly971Arg (c.2911G>A); ClinVar=VCV001337907; Zygosity=Heterozygous (from parent cell line).
Disease	Adult B acute lymphoblastic leukemia (NCIt: C9143) B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342) B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0093 (RS4;11)
Sex of cell	Female
Age at sampling	32Y
Category	Cancer cell line
Cell line collections (Providers)	KYinno; KC-1346
Entry history
Entry creation	14-Aug-2025
Last entry update	14-Aug-2025
Version number	1