Cellosaurus cell line BPS Bioscience MCF-7 PARP1 KO (CVCL

Entry history
Cell line name	BPS Bioscience MCF-7 PARP1 KO
Synonyms	PARP1 knockout MCF7
Accession	CVCL_E8DK
Resource Identification Initiative	To cite this cell line use: BPS Bioscience MCF-7 PARP1 KO (RRID:CVCL_E8DK)
Comments	Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:270; PARP1. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease	Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0031 (MCF-7)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Web pages	Provider; BPS Bioscience; 82690; https://bpsbioscience.com/parp1-knockout-mcf7-cell-line-82690
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1