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Cellosaurus Hs 578T Hc5-1 (CVCL_E8BS)

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Cell line name Hs 578T Hc5-1
Synonyms Hc5-1
Accession CVCL_E8BS
Resource Identification Initiative To cite this cell line use: Hs 578T Hc5-1 (RRID:CVCL_E8BS)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Glu168Gly and p.Met234Ile).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0332 (Hs 578T)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
Publications

PubMed=7949216; DOI=10.1007/BF00666061
Daniel Eliyahu, Steve Evans, Neal Rosen, Siona Eliyahu, James A. Zwiebel, Soonmyung Paik, Marc E. Lippman;
p53Val135 temperature sensitive mutant suppresses growth of human breast cancer cells.
Breast Cancer Res. Treat. 30:167-177(1994)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2