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Cellosaurus SK-OV-3 SK23a (CVCL_E8BP)

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Cell line name SK-OV-3 SK23a
Synonyms SK23a
Accession CVCL_E8BP
Resource Identification Initiative To cite this cell line use: SK-OV-3 SK23a (RRID:CVCL_E8BP)
Comments Population: Caucasian.
Characteristics: Transfected with mouse Trp53 p53Val135, a temperature sensitive variant that assume a wild-type configuration at 32 Celsius and transforms cells at 37 Celsius (PubMed=8152906).
Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Ala135Val = p53Val135).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=8152906; DOI=10.1093/nar/22.6.1012; PMCID=PMC307923
Faina Vikhanskaya, Eugenio Erba, Maurizio D'Incalci, Massimo Broggini;
Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53.
Nucleic Acids Res. 22:1012-1017(1994)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2