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Cellosaurus HPB-Ma clone 10-2 (CVCL_E8AU)

[Text version]
Cell line name HPB-Ma clone 10-2
Accession CVCL_E8AU
Resource Identification Initiative To cite this cell line use: HPB-Ma clone 10-2 (RRID:CVCL_E8AU)
Comments Population: Japanese.
Virology: Infected with Moloney murine leukemia virus (MoMuLV) from MiCl1 (S+L-) (Cellosaurus=CVCL_3405) cells (from parent cell line).
Virology: Supports replication of hepatitis C virus genome. Can persist up to 76 days (PubMed=8392185).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:1539; CBFB + HGNC; HGNC:29824; MYL11; Name(s)=CBFB-MYL11, CBFB-MYLPF (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys124Ter (c.372C>A); ClinVar=VCV000458537; Zygosity=Homozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E8AT (HPB-Ma)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=8392185; DOI=10.1073/pnas.90.13.6037; PMCID=PMC46862
Yohko K. Shimizu, Robert Harry Purcell, Hiroshi Yoshikura;
Correlation between the infectivity of hepatitis C virus in vivo and its infectivity in vitro.
Proc. Natl. Acad. Sci. U.S.A. 90:6037-6041(1993)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1