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Cellosaurus MOLT-4 Ma (CVCL_E8AS)

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Cell line name MOLT-4 Ma
Synonyms MOLT4 Ma; Molt4-Ma
Accession CVCL_E8AS
Resource Identification Initiative To cite this cell line use: MOLT-4 Ma (RRID:CVCL_E8AS)
Comments Population: Caucasian.
Virology: Infected with Moloney murine leukemia virus (MoMuLV) from MiCl1 (S+L-) (Cellosaurus=CVCL_3405) cells (PubMed=1319062).
Virology: Supports replication of hepatitis C virus genome (PubMed=1319062).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0013 (MOLT-4)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=1319062; DOI=10.1073/pnas.89.12.5477; PMCID=PMC49315
Yohko K. Shimizu, Aikichi Iwamoto, Minako Hijikata, Robert Harry Purcell, Hiroshi Yoshikura;
Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line.
Proc. Natl. Acad. Sci. U.S.A. 89:5477-5481(1992)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1