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Cellosaurus MDCK II CLDN2/CLDN4 dKO2 (CVCL_E7ZC)

[Text version]
Cell line name MDCK II CLDN2/CLDN4 dKO2
Synonyms MDCK II claudin-2 and claudin 4 double knockout clone 2
Accession CVCL_E7ZC
Resource Identification Initiative To cite this cell line use: MDCK II CLDN2/CLDN4 dKO2 (RRID:CVCL_E7ZC)
Comments Knockout cell: Method=TALEN; VGNC; VGNC:39316; CLDN2.
Knockout cell: Method=TALEN; VGNC; VGNC:39321; CLDN4.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy Parent: CVCL_E7Z3 (MDCK II CLDN2 KO1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=28777806; DOI=10.1371/journal.pone.0182521; PMCID=PMC5544209
Tokuda S., Hirai T., Furuse M.
Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.
PLoS ONE 12:e0182521.1-e0182521.19(2017)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1