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Cellosaurus UOK348 (CVCL_E7RD)

[Text version]
Cell line name UOK348
Accession CVCL_E7RD
Resource Identification Initiative To cite this cell line use: UOK348 (RRID:CVCL_E7RD)
Comments Doubling time: 48-72 hours (Direct_author_submission).
Miscellaneous: Age/sex of donor, doubling time, sampling site and STR profile from personal communication of Yang, You-Feng.
Derived from site: Metastatic; Pelvis; UBERON=UBERON_0002355.
Sequence variations
  • Mutation; HGNC; HGNC:3700; FH; Simple; p.Phe191Leufs*11 (c.573delT); Zygosity=Heterozygous (PubMed=33402335).
  • Mutation; HGNC; HGNC:3700; FH; Simple; p.Lys371Ter (c.1111A>T); Zygosity=Heterozygous (PubMed=33402335).
Disease Hereditary leiomyomatosis and renal cell carcinoma (NCIt: C51302)
Hereditary leiomyomatosis and renal cell cancer (ORDO: Orphanet_523)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 40Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,16
D5S81811,13
D7S82010,13
D8S117914,15
D13S31712,13
D16S53911,12
D18S5115,18
D21S1129,31.2
FGA18,22
Penta D10,13
Penta E10,14
TH018,9
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=33402335; DOI=10.1126/scisignal.abc4436; PMCID=PMC8039187
Crooks D.R., Maio N., Lang M., Ricketts C.J., Vocke C.D., Gurram S., Turan S., Kim Y.-Y., Cawthon G.M., Sohelian F., de Val N., Pfeiffer R.M., Jailwala P., Tandon M., Tran B., Fan T.W.-M., Lane A.N., Ried T., Wangsa Zong D., Malayeri A.A., Merino M.J., Yang Y.-F., Meier J.L., Ball M.W., Rouault T.A., Srinivasan R., Linehan W.M.
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.
Sci. Signal. 14:eabc4436.1-eabc4436.18(2021)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1