| Cell line name |
UOK271 |
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| Accession |
CVCL_E7RC |
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| Resource Identification Initiative |
To cite this cell line use: UOK271 (RRID:CVCL_E7RC) |
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| Comments |
Doubling time: 48-72 hours (Direct_author_submission).
Miscellaneous: Doubling time and STR profile from personal communication of Yang, You-Feng.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:3700; FH; Zygosity=Heterozygous; Note=Spontaneous loss of heterozygosity (PubMed=33402335).
- Mutation; HGNC; HGNC:3700; FH; Simple; p.Leu244Arg (c.731T>G); ClinVar=VCV000393571; Zygosity=Heterozygous (PubMed=33402335).
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| Disease |
Hereditary leiomyomatosis and renal cell carcinoma (NCIt: C51302)
Hereditary leiomyomatosis and renal cell cancer (ORDO: Orphanet_523) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Sex of cell |
Female |
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| Age at sampling |
60Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): Direct_author_submission
Markers:| Amelogenin | X |
| CSF1PO | 12 |
| D3S1358 | 14,17 |
| D5S818 | 11,12 |
| D7S820 | 10,11 |
| D8S1179 | 10,13 |
| D13S317 | 12 |
| D16S539 | 11,12 |
| D18S51 | 14,15 |
| D21S11 | 28,31.2 |
| FGA | 18,22 |
| Penta D | 9,11 |
| Penta E | 12,15 |
| TH01 | 6,9.3 |
| TPOX | 8,11 |
| vWA | 16,18 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=33402335; DOI=10.1126/scisignal.abc4436; PMCID=PMC8039187
Daniel R. Crooks, Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yun-Young Kim, Geetha Mariah Cawthon, Ferri Sohelian, Natalia de Val ...Show all 27 authors... , Ruth Maria Pfeiffer, Parthav Jailwala, Mayank Tandon, Bao Tran, Teresa Whei-Mei Fan, Andrew N. Lane, Thomas Ried, Darawalee Wangsa Zong, Ashkan A. Malayeri, Maria J. Merino, You-Feng Yang, Jordan L. Meier, Mark W. Ball, Tracey Ann Rouault, Ramaprasad Srinivasan, William Marston Linehan; Show fewer authors
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.
Sci. Signal. 14:eabc4436.1-eabc4436.18(2021) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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