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Cellosaurus UOK271 (CVCL_E7RC)

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Cell line name UOK271
Accession CVCL_E7RC
Resource Identification Initiative To cite this cell line use: UOK271 (RRID:CVCL_E7RC)
Comments Doubling time: 48-72 hours (Direct_author_submission).
Miscellaneous: Doubling time and STR profile from personal communication of Yang, You-Feng.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Gene deletion; HGNC; HGNC:3700; FH; Zygosity=Heterozygous; Note=Spontaneous loss of heterozygosity (PubMed=33402335).
  • Mutation; HGNC; HGNC:3700; FH; Simple; p.Leu244Arg (c.731T>G); ClinVar=VCV000393571; Zygosity=Heterozygous (PubMed=33402335).
Disease Hereditary leiomyomatosis and renal cell carcinoma (NCIt: C51302)
Hereditary leiomyomatosis and renal cell cancer (ORDO: Orphanet_523)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO12
D3S135814,17
D5S81811,12
D7S82010,11
D8S117910,13
D13S31712
D16S53911,12
D18S5114,15
D21S1128,31.2
FGA18,22
Penta D9,11
Penta E12,15
TH016,9.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=33402335; DOI=10.1126/scisignal.abc4436; PMCID=PMC8039187
Daniel R. Crooks, Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yun-Young Kim, Geetha Mariah Cawthon, Ferri Sohelian, Natalia de Val ...Show all 27 authors... , Ruth Maria Pfeiffer, Parthav Jailwala, Mayank Tandon, Bao Tran, Teresa Whei-Mei Fan, Andrew N. Lane, Thomas Ried, Darawalee Wangsa Zong, Ashkan A. Malayeri, Maria J. Merino, You-Feng Yang, Jordan L. Meier, Mark W. Ball, Tracey Ann Rouault, Ramaprasad Srinivasan, William Marston Linehan; Show fewer authors
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.
Sci. Signal. 14:eabc4436.1-eabc4436.18(2021)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1