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Cellosaurus HCC827/GR (CVCL_E7R9)

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Cell line name HCC827/GR
Accession CVCL_E7R9
Resource Identification Initiative To cite this cell line use: HCC827/GR (RRID:CVCL_E7R9)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=39080187; DOI=10.1007/s12094-024-03621-2
Shu-Jun Wu, Ying Liu, Xi Wang, Yan-Bei Ren, Xiang-Hong Li, Huan Wang;
PSIP1 promotes gefitinib resistance in lung adenocarcinoma by inducing the expression of WASF3 and its downstream ITGB3/AKT signaling.
Clin. Transl. Oncol. 27:507-517(2025)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1