Cellosaurus cell line MOLT-4(Cas9) (CVCL

Cellosaurus MOLT-4(Cas9) (CVCL_E7JC)

Entry history
Cell line name	MOLT-4(Cas9)
Accession	CVCL_E7JC
Resource Identification Initiative	To cite this cell line use: MOLT-4(Cas9) (RRID:CVCL_E7JC)
Comments	Population: Caucasian. Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084.
Sequence variations	Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
Disease	Adult T acute lymphoblastic leukemia (NCIt: C9142) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0013 (MOLT-4)
Sex of cell	Male
Age at sampling	19Y
Category	Cancer cell line
Web pages	Provider; BRICS; ECC3044; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3978
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1