Cellosaurus cell line HPM clone #4 (CVCL

Cellosaurus HPM clone #4 (CVCL_E7FX)

[Text version]

Cell line name

HPM clone #4

Synonyms

HP proMastocyte clone #4

Accession

CVCL_E7FX

Resource Identification Initiative

To cite this cell line use: HPM clone #4 (RRID:CVCL_E7FX)

Comments

Doubling time: 3-4 days (DOI=10.1016/j.jaci.2012.12.1081; PubMed=27459687).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Mast cell; CL=CL_0000097.

Sequence variations

Mutation; HGNC; HGNC:5163; HPS1; Simple; p.His497Glnfs*90 (c.1472_1487dup16); ClinVar=VCV000005277; Zygosity=Homozygous (DOI=10.1016/j.jaci.2012.12.1081).

Disease

Hermansky-Pudlak syndrome 1 (NCIt: C150367)
Hermansky-Pudlak syndrome with pulmonary fibrosis (ORDO: Orphanet_231500)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_E7FY (HPM clone #4-HPS1)

Originate from same individual

CVCL_E7FW ! HPM clone #3

Sex of cell

Male

Age at sampling

24-47Y

Category

Spontaneously immortalized cell line

Publications

DOI=10.1016/j.jaci.2012.12.1081
Arnold S. Kirshenbaum, Avanti Desai, Geethani Bandara, Glenn Cruse, Elizabeth R. Fischer, Alasdair M. Gilfillan, William A. Gahl, Dean D. Metcalfe;
Establishment of the Hermansky Pudlak mastocyte (HPM) cell line which has the HPS1 16-bp duplication (c.1470_1486dup16).
J. Allergy Clin. Immunol. 131 Suppl. 2:AB115.418-AB115.418(2013)

PubMed=27459687; DOI=10.1371/journal.pone.0159177; PMCID=PMC4961407
Arnold S. Kirshenbaum, Glenn Cruse, Avanti Desai, Geethani Bandara, Maarten Rudolph Leerkes, Chyi-Chia Richard Lee, Elizabeth R. Fischer, Kevin J. O'Brien, Bernadette Ruzol Gochuico, Kelly D. Stone, William A. Gahl, Dean D. Metcalfe;
Immunophenotypic and ultrastructural analysis of mast cells in Hermansky-Pudlak syndrome type-1: a possible connection to pulmonary fibrosis.
PLoS ONE 11:e0159177.1-e0159177.23(2016)

Entry history

Entry creation

10-Apr-2025

Last entry update

10-Apr-2025

Version number