Cellosaurus cell line YCU-AML2 (CVCL

Cellosaurus YCU-AML2 (CVCL_E7AL)

Entry history
Cell line name	YCU-AML2
Synonyms	Yokohama City University-Acute Myeloid Leukemia 2
Accession	CVCL_E7AL
Resource Identification Initiative	To cite this cell line use: YCU-AML2 (RRID:CVCL_E7AL)
Comments	Population: Japanese. Doubling time: 3-4 days (PubMed=39891826). Omics: Phenotyping; Drug screening. Omics: Variations; SNP array analysis. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=39891826). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=39891826). Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9; Note=KMT2A intron 8 fused to MLLT3 intron 4 (PubMed=39891826). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Homozygous (PubMed=39891826).
Disease	Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	5Y
Category	Cancer cell line
Publications	PubMed=39891826; DOI=10.1007/s12185-025-03929-x Junji Ikeda, Norio Shiba, Shota Kato, Hiroyoshi Kunimoto, Yusuke Saito, Maiko Sagisaka, Mieko Ito, Hiroaki Goto, Yusuke Okuno, Wataru Nakamura, Masahiro Yoshitomi ...Show all 16 authors... , Masanobu Takeuchi, Shuichi Ito, Hideaki Nakajima, Motohiro Kato, Shin-ichi Tsujimoto; Show fewer authors Establishment of a high-risk pediatric AML-derived cell line YCU-AML2 with genetic and metabolic vulnerabilities. Int. J. Hematol. 121:694-705(2025)
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1