Cellosaurus cell line YCU-AML2 (CVCL

Cellosaurus YCU-AML2 (CVCL_E7AL)

Entry history
Cell line name	YCU-AML2
Synonyms	Yokohama City University-Acute Myeloid Leukemia 2
Accession	CVCL_E7AL
Resource Identification Initiative	To cite this cell line use: YCU-AML2 (RRID:CVCL_E7AL)
Comments	Population: Japanese. Doubling time: 3-4 days (PubMed=39891826). Omics: Phenotyping; Drug screening. Omics: Variations; SNP array analysis. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=39891826). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=39891826). Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9; Note=KMT2A intron 8 fused to MLLT3 intron 4 (PubMed=39891826). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Homozygous (PubMed=39891826).
Disease	Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	5Y
Category	Cancer cell line
Publications	PubMed=39891826; DOI=10.1007/s12185-025-03929-x Ikeda J., Shiba N., Kato S., Kunimoto H., Saito Y., Sagisaka M., Ito M., Goto H., Okuno Y., Nakamura W., Yoshitomi M., Takeuchi M., Ito S., Nakajima H., Kato M., Tsujimoto S.-i. Establishment of a high-risk pediatric AML-derived cell line YCU-AML2 with genetic and metabolic vulnerabilities. Int. J. Hematol. 0:0-0(2025)
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1