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Cellosaurus U2OS-FGFR3 (CVCL_E7A5)

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Cell line name U2OS-FGFR3
Synonyms U2OS FGFR3; U2OS-R3
Accession CVCL_E7A5
Resource Identification Initiative To cite this cell line use: U2OS-FGFR3 (RRID:CVCL_E7A5)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3690; FGFR3.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Web pages Provider; I2B; P-96; http://inven2biologics.com/shop/cell-lines/human/u2os-fgfr3-osteosarcoma-cell-line
Publications

PubMed=21779335; DOI=10.1371/journal.pone.0021708; PMCID=PMC3136467
Ellen Margrethe Haugsten, Malgorzata Zakrzewska, Andreas Brech, Sascha Pust, Sjur Olsnes, Kirsten Sandvig, Jorgen Wesche;
Clathrin- and dynamin-independent endocytosis of FGFR3 -- implications for signalling.
PLoS ONE 6:e21708.1-e21708.13(2011)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2