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Cellosaurus U2OS-FGFR1 25Rc (CVCL_E7A2)

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Cell line name U2OS-FGFR1 25Rc
Synonyms U2OS-R1 25Rc
Accession CVCL_E7A2
Resource Identification Initiative To cite this cell line use: U2OS-FGFR1 25Rc (RRID:CVCL_E7A2)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3688; FGFR1 (Note=With in the intracellular domain 15 Lys mutated to Arg).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=18480409; DOI=10.1091/mbc.e07-12-1219; PMCID=PMC2488279
Ellen Margrethe Haugsten, Jedrzej M. Malecki, Sunniva Maria Stordal Bjorklund, Sjur Olsnes, Jorgen Wesche;
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.
Mol. Biol. Cell 19:3390-3403(2008)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2