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Cellosaurus HCC827-TK (CVCL_E6ZQ)

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Cell line name HCC827-TK
Accession CVCL_E6ZQ
Resource Identification Initiative To cite this cell line use: HCC827-TK (RRID:CVCL_E6ZQ)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (PubMed=32163227).
  • Mutation; HGNC; HGNC:3676; FGF2; Simple; p.Gly34Val (c.101G>T); Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=32163227).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=32163227; DOI=10.1111/1759-7714.13342; PMCID=PMC7180561
Tao Yu, Qian Xia, Ting Gong, Jing Wang, Dian-Sheng Zhong;
Molecular mechanism of acquired drug resistance in the EGFR-TKI resistant cell line HCC827-TR.
Thorac. Cancer 11:1129-1138(2020)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1