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Cellosaurus KS24 (CVCL_E6X7)

[Text version]
Cell line name KS24
Synonyms KS 24; KS-CD80
Accession CVCL_E6X7
Resource Identification Initiative To cite this cell line use: KS24 (RRID:CVCL_E6X7)
Comments Characteristics: Transfection of CD80 has resulted in improved primary T cell activation (PubMed=9384677).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1700; CD80.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E6X5 (KS [Human breast carcinoma])
Children:
CVCL_E6XJ (KS24-M1)CVCL_E6X8 (KS24.22)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=9384677
Guckel B., Lindauer M., Rudy W., Habicht A., Siebels M., Kaul S., Bastert G., Meuer S.C., Moebius U.
CD80-transfected human breast and ovarian tumor cell lines: improved immunogenicity and induction of cytolytic CD8+ T lymphocytes.
Cytokines Mol. Ther. 1:211-221(1995)

PubMed=10359208; DOI=10.1038/sj.cgt.7700050
Guckel B., Meyer G.C., Rudy W., Batrla R., Meuer S.C., Bastert G., Wallwiener D., Moebius U.
Interleukin-12 requires initial CD80-mediated T-cell activation to support immune responses toward human breast and ovarian carcinoma.
Cancer Gene Ther. 6:228-237(1999)

PubMed=10359214; DOI=10.1038/sj.cgt.7700054
Meyer G.C., Batrla R., Rudy W., Meuer S.C., Wallwiener D., Guckel B., Moebius U.
Potential of CD80-transfected human breast carcinoma cells to induce peptide-specific T lymphocytes in an allogeneic human histocompatibility leukocyte antigens (HLA)-A2.1+-matched situation.
Cancer Gene Ther. 6:282-288(1999)

PubMed=15365776; DOI=10.1007/s00262-004-0583-z; PMCID=PMC11034349
Guckel B., Stumm S., Rentzsch C., Marme A., Mannhardt G., Wallwiener D.
A CD80-transfected human breast cancer cell variant induces HER-2/neu-specific T cells in HLA-A*02-matched situations in vitro as well as in vivo.
Cancer Immunol. Immunother. 54:129-140(2005)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1