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Cellosaurus NHBE-BMI-1 (CVCL_E6IM)

[Text version]
Cell line name NHBE-BMI-1
Synonyms Normal Human Bronchial Epithelial cells-BMI-1 transduced
Accession CVCL_E6IM
Resource Identification Initiative To cite this cell line use: NHBE-BMI-1 (RRID:CVCL_E6IM)
Comments Senescence: Senesces at 25 PDL (PubMed=27979861).
Doubling time: 1.25 days (Note=At 12th passage), 1.21 days (Note=At 15th passage), 1.49 days (Note=At 23th passage) (PubMed=27979861).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1066; BMI1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Finite cell line
Web pages Provider; UCLB; -; https://xip.uclb.com/product/bmi-1-transduced-basal-epithelial-cells
Publications

PubMed=27979861; DOI=10.1152/ajplung.00471.2016; PMCID=PMC5336581
Mustafa Mohammed Munye, Amelia Shoemark, Robert A. Hirst, Juliette M. Delhove, Tyson Valentine Sharp, Tristan R. Mckay, Christopher O'Callaghan, Deborah L. Baines, Steven J. Howe, Stephen L. Hart;
BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.
Am. J. Physiol. Lung Cell. Mol. Physiol. 312:L258-L267(2017)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2