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Cellosaurus K562 #10 NIL (CVCL_E6IG)

[Text version]
Cell line name K562 #10 NIL
Accession CVCL_E6IG
Resource Identification Initiative To cite this cell line use: K562 #10 NIL (RRID:CVCL_E6IG)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_52172; Nilotinib (AMN107; Tasigna).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=27536777; DOI=10.1371/journal.pone.0161470; PMCID=PMC4990177
Laura N. Eadie, Timothy P. Hughes, Deborah L. White;
ABCB1 overexpression is a key initiator of resistance to tyrosine kinase inhibitors in CML cell lines.
PLoS ONE 11:e0161470.1-e0161470.18(2016)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1