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Cellosaurus K562(Pgp) (CVCL_E6HW)

[Text version]
Cell line name K562(Pgp)
Accession CVCL_E6HW
Resource Identification Initiative To cite this cell line use: K562(Pgp) (RRID:CVCL_E6HW)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:40; ABCB1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=12881321; DOI=10.1182/blood-2003-01-0083
Ferrao P.T., Frost M.J., Siah S.-P., Ashman L.K.
Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro.
Blood 102:4499-4503(2003)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1