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Cellosaurus iMMEC WT3 (CVCL_E6BV)

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Cell line name iMMEC WT3
Synonyms immortalized Mouse Mammary Epithelial Cell line WT3
Accession CVCL_E6BV
Resource Identification Initiative To cite this cell line use: iMMEC WT3 (RRID:CVCL_E6BV)
Comments Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Human adenovirus C serotype 5 E1A protein.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_E6CB (iMMEC WT3-LC3)CVCL_E6C5 (iMMEC WT3.B1)CVCL_E6C6 (iMMEC WT3.B2)
CVCL_E6C7 (iMMEC WT3.B3)CVCL_E6C8 (iMMEC WT3.B8)CVCL_E6C2 (iMMEC WT3.V)
Sex of cell Female
Age at sampling 6-8W
Category Transformed cell line
Publications

PubMed=17606641; DOI=10.1101/gad.1565707; PMCID=PMC1899472
Vassiliki Karantza-Wadsworth, Shyam Patel, Olga Kravchuk, Guang-Hua Chen, Robin Mathew, Sheng-Kan Jin, Eileen White;
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.
Genes Dev. 21:1621-1635(2007)

PubMed=18603116; DOI=10.1016/S0076-6879(08)01604-2; PMCID=PMC2857708
Vassiliki Karantza-Wadsworth, Eileen White;
A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression.
Methods Enzymol. 446:61-76(2008)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2