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Cellosaurus iETF-Mecp2-R294X (CVCL_E6BQ)

[Text version]
Cell line name iETF-Mecp2-R294X
Accession CVCL_E6BQ
Resource Identification Initiative To cite this cell line use: iETF-Mecp2-R294X (RRID:CVCL_E6BQ)
Comments Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Ear, skin; UBERON=UBERON_0001459.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; MGI; MGI:99918; Mecp2; Simple_edited; p.Arg294Ter; Zygosity=Hemizygous; Note=By CRISPR/Cas9. In the mouse line (PubMed=32469049).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=32469049; DOI=10.1093/hmg/ddaa102; PMCID=PMC7471501
Merritt J.K., Collins B.E., Erickson K.R., Dong H.-W., Neul J.L.
Pharmacological read-through of R294X Mecp2 in a novel mouse model of Rett syndrome.
Hum. Mol. Genet. 29:2461-2470(2020)

Cross-references
Cell line collections (Providers) ABM; T0871
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1