Cellosaurus ECoM-G (CVCL_E6BC)
| Cell line name | ECoM-G |
|---|---|
| Synonyms | E2a/Pbx1-mediated Conditional Myeloid-Granulocyte |
| Accession | CVCL_E6BC |
| Resource Identification Initiative | To cite this cell line use: ECoM-G (RRID:CVCL_E6BC) |
| Comments | Characteristics: Exhibits restricted granulocytic differentiation. Neutrophil progenitor cells that express a conditional form of TCF3-PBX1 (E2a-Pbx1) in an estrogen responsive manner (PubMed=11588024). Characteristics: CSF2 dependent. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3467; ESR1 (Note=With p.Met1_Gly281del and p.Gly400Val in a E2a/Pbx1Delta487-623ER fusion = EPD623ER). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8632; PBX1 (Note=With p.Met1_Asp232del in a E2a/Pbx1Delta487-623ER fusion = EPD623ER). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11633; TCF3 (Note=With p.Gly484_Met654del in a E2a/Pbx1Delta487-623ER fusion = EPD623ER). Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Transformant: TCF3-PBX1 (E2A-PBX1). Omics: Transcriptomics; Microarray. Caution: Breed of donor mouse erroneously indicated as being from BALB/c in PubMed=11588024. Correct breed from personal communication of Sykes, David Brian through ABM. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. Cell type: Mononuclear cell of bone marrow; CL=CL_0010004. |
| Species of origin | Mus musculus (Mouse)
(NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6. |
| Sex of cell | Female |
| Age at sampling | Age unspecified |
| Category | Transformed cell line |
| Publications | PubMed=11588024; DOI=10.1182/blood.v98.8.2308 PubMed=12916872; DOI=10.1080/1042819031000090273 |
| Cross-references | |
| Cell line collections (Providers) | ABM; T0200 |
| Entry history | |
| Entry creation | 10-Apr-2025 |
| Last entry update | 10-Apr-2025 |
| Version number | 1 |