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Cellosaurus DG-75 CBF1 KO clone SM261D11 (CVCL_E5V9)

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Cell line name DG-75 CBF1 KO clone SM261D11
Synonyms SM261D11
Accession CVCL_E5V9
Resource Identification Initiative To cite this cell line use: DG-75 CBF1 KO clone SM261D11 (RRID:CVCL_E5V9)
Comments Population: Jewish; Ashkenazi.
Virology: EBV-negative.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:5724; RBPJ (Note=3 of 3 alleles).
Genetic integration: Method=Homologous recombination; Gene=FPbase; TXLFX; DsRed2 (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Genetic integration: Method=Homologous recombination; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg283His (c.848G>A); ClinVar=VCV000142324; Zygosity=Heterozygous (from parent cell line).
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E5V8 (DG-75 CBF1 KO clone SM267C18)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
Publications

PubMed=15994772; DOI=10.1128/JVI.79.14.8784-8792.2005; PMCID=PMC1168782
Sabine Maier, Maja Santak, Anja Mantik, Kristina Grabusic, Elisabeth Kremmer, Wolfgang Hammerschmidt, Bettina Kempkes;
A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent.
J. Virol. 79:8784-8792(2005)

Cross-references
Cell line collections (Providers) ABM; T6056
Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2