Cellosaurus cell line DG-75 CBF1 KO clone SM223E3 (CVCL

Cellosaurus DG-75 CBF1 KO clone SM223E3 (CVCL_E5V7)

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Cell line name

DG-75 CBF1 KO clone SM223E3

Accession

CVCL_E5V7

Resource Identification Initiative

To cite this cell line use: DG-75 CBF1 KO clone SM223E3 (RRID:CVCL_E5V7)

Comments

Population: Jewish; Ashkenazi.
Virology: EBV-negative.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:5724; RBPJ (Note=2 of 3 alleles).
Genetic integration: Method=Homologous recombination; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Homologous recombination; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.

Sequence variations

Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg283His (c.848G>A); ClinVar=VCV000142324; Zygosity=Heterozygous (from parent cell line).

Disease

Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_E5V6 (DG-75 CBF1 KO clone SM224.9)
Children:

CVCL_E5V8 (DG-75 CBF1 KO clone SM267C18)

Sex of cell

Male

Age at sampling

10Y