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Cellosaurus SF295 MX250 (CVCL_E5T8)

[Text version]
Cell line name SF295 MX250
Accession CVCL_E5T8
Resource Identification Initiative To cite this cell line use: SF295 MX250 (RRID:CVCL_E5T8)
Comments Population: Caucasian.
Characteristics: Resistant to 250 nM of mitoxantrone (PubMed=15993268).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Brain, left temporal lobe; UBERON=UBERON_0002808.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1690 (SF295)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=15993268; DOI=10.1016/j.cancergencyto.2004.12.013
V. Koneti Rao, Darawalee Wangsa Zong, Robert W. Robey, Lyn Mickley Huff, Yasumasa Honjo, Jeffrey Hung, Turid Knutsen, Thomas Ried, Susan E. Bates;
Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.
Cancer Genet. Cytogenet. 160:126-133(2005)

Cross-references
Cell line collections (Providers) ABM; T8040
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1