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Cellosaurus MCF-7 FLV100 (CVCL_E5SX)

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Cell line name MCF-7 FLV100
Synonyms MCF-7-FLV100
Accession CVCL_E5SX
Resource Identification Initiative To cite this cell line use: MCF-7 FLV100 (RRID:CVCL_E5SX)
Comments Population: Caucasian.
Characteristics: Resistant to 100 nM of flavopiridol (PubMed=11205902).
Selected for resistance to: ChEBI; CHEBI_47344; Alvocidib (Flavopiridol; HMR-1275).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11205902
Robert W. Robey, Wilma Y. Medina-Perez, Kenryu Nishiyama, Tyler Lahusen, Keisuke Miyake, Thomas Litman, Adrian M. Senderowicz, Douglas D. Ross, Susan E. Bates;
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Clin. Cancer Res. 7:145-152(2001)

PubMed=12642696; DOI=10.4161/cbt.322
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates;
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002)

Cross-references
Cell line collections (Providers) ABM; T8033
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1