Cellosaurus logo
expasy logo

Cellosaurus COV362 RRAS2 KO#5 (CVCL_E5L5)

[Text version]
Cell line name COV362 RRAS2 KO#5
Accession CVCL_E5L5
Resource Identification Initiative To cite this cell line use: COV362 RRAS2 KO#5 (RRID:CVCL_E5L5)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17271; RRAS2.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Pro871fs (c.2611_2612ins1); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; c.4095+1G>T; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2420 (COV362)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=36476833; DOI=10.1038/s41388-022-02563-9; PMCID=PMC9883167
Clavain L., Fernandez-Pisonero M.I., Movilla N., Lorenzo-Martin L.F., Nieto B., Abad A., Garcia-Navas R., Llorente-Gonzalez C., Sanchez-Martin M., Vicente-Manzanares M., Santos E., Alarcon B., Garcia-Aznar J.M., Dosil M., Bustelo X.R.
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene 42:389-405(2023)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1