| Cell line name |
COV362 RRAS2 KO#1 |
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| Accession |
CVCL_E5L4 |
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| Resource Identification Initiative |
To cite this cell line use: COV362 RRAS2 KO#1 (RRID:CVCL_E5L4) |
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| Comments |
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17271; RRAS2.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Pro871fs (c.2611_2612ins1); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1100; BRCA1; Simple; c.4095+1G>T; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
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| Disease |
High grade ovarian serous adenocarcinoma (NCIt: C105555) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2420 (COV362) |
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| Sex of cell |
Female |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=36476833; DOI=10.1038/s41388-022-02563-9; PMCID=PMC9883167
Laura Clavain, Maria Isabel Fernandez-Pisonero, Nieves Movilla, Luis Francisco Lorenzo-Martin, Blanca Nieto, Antonio Abad, Rosula Garcia-Navas, Clara Llorente-Gonzalez, Manuel Sanchez-Martin, Miguel Vicente-Manzanares, Eugenio Santos ...Show all 15 authors... , Balbino Alarcon, Jose Manuel Garcia-Aznar, Mercedes Dosil, Xose R. Bustelo; Show fewer authors
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene 42:389-405(2023) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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