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Cellosaurus U266-PSR (CVCL_E5J9)

[Text version]
Cell line name U266-PSR
Synonyms U266PSR
Accession CVCL_E5J9
Resource Identification Initiative To cite this cell line use: U266-PSR (RRID:CVCL_E5J9)
Comments Population: Caucasian.
Characteristics: Resistant to 15 nM of bortezomib (DOI=10.1182/blood.V124.21.2084.2084).
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

DOI=10.1182/blood.V124.21.2084.2084
Turner J.G., Dawson J.L., Grant S., Shain K.H., Dai Y., Cubitt C.L., Baz R.C., Nishihori T., Kauffman M.G., Shacham S., Sullivan D.M.
Melphalan and XPO1 inhibitor combination therapy for the treatment of multiple myeloma.
Blood 124 Suppl. 1:2084-2084(2014)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1