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Cellosaurus U266-PSR (CVCL_E5J9)

[Text version]
Cell line name U266-PSR
Synonyms U266PSR
Accession CVCL_E5J9
Resource Identification Initiative To cite this cell line use: U266-PSR (RRID:CVCL_E5J9)
Comments Population: Caucasian.
Characteristics: Resistant to 15 nM of bortezomib (DOI=10.1182/blood.V124.21.2084.2084).
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0566 (U266B1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

DOI=10.1182/blood.V124.21.2084.2084
Joel G. Turner, Jana L. Dawson, Steven Grant, Kenneth H. Shain, Yun Dai, Christopher L. Cubitt, Rachid Chafic Baz, Taiga Nishihori, Michael G. Kauffman, Sharon Shacham, Daniel M. Sullivan;
Melphalan and XPO1 inhibitor combination therapy for the treatment of multiple myeloma.
Blood 124 Suppl. 1:2084-2084(2014)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2