Cellosaurus cell line SP-01-OT-CL (CVCL

Cellosaurus SP-01-OT-CL (CVCL_E5GN)

Entry history
Cell line name	SP-01-OT-CL
Accession	CVCL_E5GN
Resource Identification Initiative	To cite this cell line use: SP-01-OT-CL (RRID:CVCL_E5GN)
Comments	Population: Caucasian; Spanish. Characteristics: Established from the athymic nude mice SP-01-OT orthotopic xenograft (PubMed=37798904). Doubling time: 2.72 days (PubMed=37798904). Omics: Genomics; Whole exome sequencing. Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations	Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=37798904). Mutation; HGNC; HGNC:3432; ERBB4; Simple; p.Arg612Trp (c.1834C>T); Zygosity=Heterozygous (PubMed=37798904). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Heterozygous (PubMed=37798904).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_E5GM ! SP-01-CL
Sex of cell	Male
Age at sampling	88Y
Category	Cancer cell line
Publications	PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238 Creus-Bachiller E., Fernandez-Rodriguez J., Magallon-Lorenz M., Ortega-Bertran S., Navas-Rutete S., Romagosa C., Silva T.M., Pane Foix M., Estival A., Perez Sidelnikova D., Morell Ginesta M., Mazuelas H., Carrio M., Lausova T., Reuss D.E., Gel B., Villanueva A., Serra E., Lazaro C. Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities. Mol. Oncol. 18:895-917(2024)
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1