Cellosaurus cell line SP-01-OT-CL (CVCL

Cellosaurus SP-01-OT-CL (CVCL_E5GN)

Entry history
Cell line name	SP-01-OT-CL
Accession	CVCL_E5GN
Resource Identification Initiative	To cite this cell line use: SP-01-OT-CL (RRID:CVCL_E5GN)
Comments	Population: Caucasian; Spanish. Characteristics: Established from the athymic nude mice SP-01-OT orthotopic xenograft (PubMed=37798904). Doubling time: 2.72 days (PubMed=37798904). Omics: Genomics; Whole exome sequencing. Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations	Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=37798904). Mutation; HGNC; HGNC:3432; ERBB4; Simple; p.Arg612Trp (c.1834C>T); Zygosity=Heterozygous (PubMed=37798904). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Heterozygous (PubMed=37798904).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_E5GM ! SP-01-CL
Sex of cell	Male
Age at sampling	88Y
Category	Cancer cell line
Publications	PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238 Edgar Creus-Bachiller, Juana Fernandez-Rodriguez, Miriam Magallon-Lorenz, Sara Ortega-Bertran, Susana Navas-Rutete, Cleofe Romagosa, Tulio M. Silva, Maria Pane Foix, Anna Estival, Diana Perez Sidelnikova, Mireia Morell Ginesta ...Show all 19 authors... , Helena Mazuelas, Meritxell Carrio, Tereza Lausova, David E. Reuss, Bernat Gel, Alberto Villanueva, Eduard Serra, Conxi Lazaro; Show fewer authors Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities. Mol. Oncol. 18:895-917(2024)
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1