| Cell line name |
NF1-09-CL |
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| Synonyms |
MPNST-NF1-09-CL |
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| Accession |
CVCL_E5GL |
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| Resource Identification Initiative |
To cite this cell line use: NF1-09-CL (RRID:CVCL_E5GL) |
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| Comments |
Population: Caucasian; Spanish.
Characteristics: Tumorigenic (PubMed=37798904).
Doubling time: 0.44 day (PubMed=37798904).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Peripheral nervous system, sciatic nerve; UBERON=UBERON_0001322. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=37798904).
- Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=37798904).
- Mutation; HGNC; HGNC:7765; NF1; Simple; c.1186-5_1186-1del; Zygosity=Heterozygous; Note=Somatic (PubMed=37798904).
- Mutation; HGNC; HGNC:7765; NF1; Simple; p.Tyr2285Ter (c.6855C>A) (p.Tyr2264Ter, c.6792C>A); ClinVar=VCV000185082; Zygosity=Heterozygous; Note=Germline (PubMed=37798904).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Heterozygous (PubMed=37798904).
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| Disease |
Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Sex of cell |
Female |
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| Age at sampling |
35Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238
Edgar Creus-Bachiller, Juana Fernandez-Rodriguez, Miriam Magallon-Lorenz, Sara Ortega-Bertran, Susana Navas-Rutete, Cleofe Romagosa, Tulio M. Silva, Maria Pane Foix, Anna Estival, Diana Perez Sidelnikova, Mireia Morell Ginesta ...Show all 19 authors... , Helena Mazuelas, Meritxell Carrio, Tereza Lausova, David E. Reuss, Bernat Gel, Alberto Villanueva, Eduard Serra, Conxi Lazaro; Show fewer authors
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities.
Mol. Oncol. 18:895-917(2024) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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