| Cell line name |
NF1-09-CL |
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| Synonyms |
MPNST-NF1-09-CL |
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| Accession |
CVCL_E5GL |
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| Resource Identification Initiative |
To cite this cell line use: NF1-09-CL (RRID:CVCL_E5GL) |
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| Comments |
Population: Caucasian; Spanish.
Characteristics: Tumorigenic (PubMed=37798904).
Doubling time: 0.44 day (PubMed=37798904).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Peripheral nervous system, sciatic nerve; UBERON=UBERON_0001322. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=37798904).
- Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=37798904).
- Mutation; HGNC; HGNC:7765; NF1; Simple; c.1186-5_1186-1del; Zygosity=Heterozygous; Note=Somatic (PubMed=37798904).
- Mutation; HGNC; HGNC:7765; NF1; Simple; p.Tyr2285Ter (c.6855C>A) (p.Tyr2264Ter, c.6792C>A); ClinVar=VCV000185082; Zygosity=Heterozygous; Note=Germline (PubMed=37798904).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Heterozygous (PubMed=37798904).
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| Disease |
Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Sex of cell |
Female |
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| Age at sampling |
35Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238
Creus-Bachiller E., Fernandez-Rodriguez J., Magallon-Lorenz M., Ortega-Bertran S., Navas-Rutete S., Romagosa C., Silva T.M., Pane Foix M., Estival A., Perez Sidelnikova D., Morell Ginesta M., Mazuelas H., Carrio M., Lausova T., Reuss D.E., Gel B., Villanueva A., Serra E., Lazaro C.
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities.
Mol. Oncol. 18:895-917(2024) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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