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Cellosaurus HEK293 GSK3B KO (CVCL_E5GF)

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Cell line name HEK293 GSK3B KO
Synonyms HEK293 GSK-3beta KO
Accession CVCL_E5GF
Resource Identification Initiative To cite this cell line use: HEK293 GSK3B KO (RRID:CVCL_E5GF)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4617; GSK3B.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=35339896; DOI=10.1016/j.ebiom.2022.103970; PMCID=PMC8956943
Qiu-Zhi Zhou, Shi-Hong Li, Meng-Zhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, En-Jie Liu, Jian-Zhi Wang;
Human tau accumulation promotes glycogen synthase kinase-3beta acetylation and thus upregulates the kinase: a vicious cycle in Alzheimer neurodegeneration.
EBioMedicine 78:103970.1-103970.18(2022)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2