Cellosaurus logo
expasy logo

Cellosaurus (CVCL_E5G7)

[Text][XML][JSON]
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-537.
Population: Caucasian.
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Uterus; UBERON=UBERON_0000995.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1096Ter (c.3286C>T); ClinVar=VCV000156475; Zygosity=Heterozygous (ATCC=HTB-114).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (ATCC=HTB-114).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg88Gln (c.263G>A); ClinVar=VCV000376049; Zygosity=Heterozygous (ATCC=HTB-114).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (ATCC=HTB-114).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn323fs*2 (c.968_969insA); Zygosity=Heterozygous (ATCC=HTB-114).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); ClinVar=VCV002724056; Zygosity=Homozygous (ATCC=HTB-114).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (PubMed=2216456; ATCC=HTB-114).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=2216456; ATCC=HTB-114).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*44:02,55:01
HLA-CC*01:02,05:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.59
Native American1.42
East Asian, North0
East Asian, South1.64
South Asian7.64
European, North32.8
European, South54.91
Disease Uterine corpus leiomyosarcoma (NCIt: C6340)
Leiomyosarcoma of the corpus uteri (ORDO: Orphanet_213625)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0017007/5008; ATCC=HTB-114; CLS=300455; Cosmic-CLP=909732

Markers:
AmelogeninX
CSF1PO10,11
D2S133818,19,21
D3S135815,16
D5S81810,11
D7S8209,10
D8S117913,15
D13S31713
D16S53913,14
D18S5111,16
D19S43312,13
D21S1129,32.2
FGA22,24
Penta D11,14,15 (ATCC=HTB-114)
11,15 (CLS=300455)
Penta E17
TH017
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Web pages Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-ut-1-human-uterine-leiomyosarcoma-cell-line
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42