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Cellosaurus COX (CVCL_E534)

[Text version]
Cell line name COX
Accession CVCL_E534
Resource Identification Initiative To cite this cell line use: COX (RRID:CVCL_E534)
Comments Part of: 10th International Histocompatibility Workshop (10IHW) cell line panel.
Population: Caucasian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; MHC region sequencing.
Omics: Proteomics; HLA class II peptidome.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
HLA typing Source: IPD-IMGT/HLA=10429
Class I
HLA-AA*01:01:01:01
HLA-BB*08:01:01:01
HLA-CC*07:01:01:01
Class II
HLA-DPDPA1*01:03:01:03
DPB1*03:01:01
HLA-DQDQA1*05:01:01
DQB1*02:01:01
HLA-DRDRA*01:02
DRB1*03:01:01
DRB3*01:01:02:01

Source: PubMed=30844424
Class I
HLA-AA*01:01:01:01
HLA-BB*08:01:01:01
HLA-CC*07:01:01:01
Class II
HLA-DPDPA1*01:03:01:03
DPB1*03:01:01
HLA-DQDQA1*05:01:01:02
DQB1*02:01:01
HLA-DRDRB1*03:01:01
DRB3*01:01:02
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
Publications

DOI=10.1007/978-1-4612-3552-1_2
Soo Young Yang, Edgar Louis Milford, Ulrich Hammerling, Bo Dupont;
Description of the reference panel of B-lymphoblastoid cell lines for factors of the HLA system: the B-cell line panel designed for the Tenth International Histocompatibility Workshop.
(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont, Bo (eds.); pp.11-19; Springer; New York; USA (1989)

DOI=10.1007/978-1-4612-3552-1_4
Eric M. Mickelson, Nancy Louise Reinsmoen, Fu-Meei Robbins, Robert J. Hartzman, Niels Odum, Arne Svejgaard, Caroline Farrell, Margo C. Honeyman, Neal Flomenberg, Thomas W. Sell, David D. Eckels;
HLA-Dw and HLA-DP typing of the reference panel of B-lymphoblastoid cell lines.
(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont, Bo (eds.); pp.38-42; Springer; New York; USA (1989)

DOI=10.1007/978-1-4612-3552-1_5
Soo Young Yang;
Assignment of HLA-A and HLA-B antigens for the reference panel of B-lymphoblastoid cell lines determined by one-dimensional isoelectric focusing (lD-IEF) gel electrophoresis.
(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont, Bo (eds.); pp.43-44; Springer; New York; USA (1989)

DOI=10.1007/978-1-4612-3552-1_6
Robert W. Knowles;
Assignment of HLA-class II alpha and beta chain 2-D gel patterns for the workshop reference panel of B-lymphoblastoid cell lines.
(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont, Bo (eds.); pp.44-46; Springer; New York; USA (1989)

DOI=10.1007/978-1-4612-3552-1_7
Neal Flomenberg;
Assignment of T-cell-defined (TCD) HLA class II specificities for the reference panel of B-lymphoblastoid cell lines.
(In book chapter) Immunobiology of HLA. Volume I. Histocompatibility testing 1987; Dupont, Bo (eds.); pp.46-48; Springer; New York; USA (1989)

PubMed=8307784; DOI=10.1016/0198-8859(93)90514-2
Mariapia A. Degli-Esposti, Michael S.J. Griffiths, Louise N. Daly, Campbell S. Witt, Malcolm Simons, Carlo Carcassi, Ekkehard D. Albert, Marius J. Giphart, Roger L. Dawkins;
Characterization of 4AOHW cell line panel including new data for the 10IHW panel.
Hum. Immunol. 38:3-16(1993)

PubMed=8813743; DOI=10.1111/j.1399-0039.1996.tb02596.x
Vinod K. Prasad, Soo Young Yang;
Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines.
Tissue Antigens 47:538-546(1996)

PubMed=15140828; DOI=10.1101/gr.2188104; PMCID=PMC419796
C. Andrew Stewart, Roger Horton, Richard J.N. Allcock, Jennifer L. Ashurst, Alexey M. Atrazhev, Penny Coggill, Ian Dunham, Simon Forbes, Karen Halls, Joanna M.M. Howson, Sean J. Humphray ...Show all 26 authors... , Sarah Hunt, Andrew J. Mungall, Kazutoyo Osoegawa, Sophie Palmer, Anne N. Roberts, Jane Rogers, Sarah Sims, Yu Wang, Laurens G. Wilming, John F. Elliott, Pieter J. de Jong, Stephen Sawcer, John Andrew Todd, John Trowsdale, Stephan Beck; Show fewer authors
Complete MHC haplotype sequencing for common disease gene mapping.
Genome Res. 14:1176-1187(2004)

PubMed=16440057; DOI=10.1371/journal.pgen.0020009; PMCID=PMC1331980
James A. Traherne, Roger Horton, Anne N. Roberts, Marcos M. Miretti, Matthew Edward Hurles, C. Andrew Stewart, Jennifer L. Ashurst, Alexey M. Atrazhev, Penny Coggill, Sophie Palmer, Jeff Almeida-King ...Show all 21 authors... , Sarah Sims, Laurens G. Wilming, Jane Rogers, Pieter J. de Jong, Mary N. Carrington, John F. Elliott, Stephen Sawcer, John Andrew Todd, John Trowsdale, Stephan Beck; Show fewer authors
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.
PLoS Genet. 2:e9.1-e9.12(2006)

PubMed=16702430; DOI=10.1534/genetics.106.057034; PMCID=PMC1526686
Takashi Shiina, Masao Ota, Sayoko Shimizu, Yoshihiko Katsuyama, Nami Hashimoto, Miwa Takasu, Tatsuya Anzai, Jerzy K. Kulski, Eri Kikkawa, Taeko Naruse, Natsuki Kimura ...Show all 26 authors... , Kazuyo Yanagiya, Atsushi Watanabe, Kazuyoshi Hosomichi, Sakae Kohara, Chie Iwamoto, Yumi Umehara, Alice Meyer, Valerie Wanner, Kazumi Sano, Cecile Macquin, Kazuho Ikeo, Katsushi Tokunaga, Takashi Gojobori, Hidetoshi Inoko, Seiamak Bahram; Show fewer authors
Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.
Genetics 173:1555-1570(2006)

PubMed=18193213; DOI=10.1007/s00251-007-0262-2; PMCID=PMC2206249
Roger Horton, Richard Gibson, Penny Coggill, Marcos M. Miretti, Richard J.N. Allcock, Jeff Almeida-King, Simon Forbes, James G.R. Gilbert, Karen Halls, Jennifer L. Harrow, Elizabeth Hart ...Show all 27 authors... , Kevin L. Howe, David K. Jackson, Sophie Palmer, Anne N. Roberts, Sarah Sims, C. Andrew Stewart, James A. Traherne, Steve Trevanion, Laurens G. Wilming, Jane Rogers, Pieter J. de Jong, John F. Elliott, Stephen Sawcer, John Andrew Todd, John Trowsdale, Stephan Beck; Show fewer authors
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.
Immunogenetics 60:1-18(2008)

PubMed=28360230; DOI=10.1101/gr.213538.116; PMCID=PMC5411776
Paul J. Norman, Steven J. Norberg, Lisbeth A. Guethlein, Neda Nemat-Gorgani, Thomas Royce, Emily E. Wroblewski, Tamsen Dunn, Tobias Mann, Claudia Alicata, Jill A. Hollenbach, Wei-Hua Chang ...Show all 16 authors... , Melissa Shults Won, Kevin L. Gunderson, Laurent Abi-Rached, Mostafa Ronaghi, Peter Parham; Show fewer authors
Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Genome Res. 27:813-823(2017)

PubMed=29171935; DOI=10.1111/tan.13184
Thomas R. Turner, James David Hayhurst, Daniel R. Hayward, Will P. Bultitude, Dominic J. Barker, James Robinson, J. Alejandro Madrigal, Neema P. Mayor, Steven G.E. Marsh;
Single molecule real-time DNA sequencing of HLA genes at ultra-high resolution from 126 international HLA and immunogenetics workshop cell lines.
HLA 91:88-101(2018)

PubMed=30844424; DOI=10.1016/j.humimm.2019.03.001; PMCID=PMC6599558
Lisa E. Creary, Sandra G. Guerra, Winnie Chong, Colin J. Brown, Thomas R. Turner, James Robinson, Will P. Bultitude, Neema P. Mayor, Steven G.E. Marsh, Katsuyuki Saito, Kevin Lam ...Show all 41 authors... , Jamie L. Duke, Timothy L. Mosbruger, Deborah Ferriola, Dimitrios S. Monos, Amanda Willis, Medhat Askar, Gottfried F. Fischer, Chee Loong Saw, Jiannis Ragoussis, Martin Petrek, Carles Serra-Pages, Manel Juan Otero, Catherine Stavropoulos-Giokas, Amalia Dinou, Reem Ameen, Salem Al Shemmari, Eric Spierings, Ketevan Gendzekhadze, Gerald P. Morris, Qiu-Heng Zhang, Zahra Kashi, Susan Hsu, Sridevi Gangavarapu, Kalyan C. Mallempati, Fumiko Yamamoto, Kazutoyo Osoegawa, Tamara Vayntrub, Chia-Jung Chang, John A. Hansen, Marcelo A. Fernandez-Vina; Show fewer authors
Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.
Hum. Immunol. 80:449-460(2019)

Cross-references
Cell line collections (Providers) CLS; 302138
Cell line databases/resources dbMHC; 48733
IHW; IHW09022
IPD-IMGT/HLA; 10429
Encyclopedic resources Wikidata; Q54814358
Proteomic databases PRIDE; PXD017682
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number21