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Cellosaurus CHO.IAR-4 (CVCL_E4I5)

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Cell line name CHO.IAR-4
Synonyms CHO.IAR
Accession CVCL_E4I5
Resource Identification Initiative To cite this cell line use: CHO.IAR-4 (RRID:CVCL_E4I5)
Comments Characteristics: Transfected with a hybrid human insulin receptor (INSR), bacterial aspartate receptor (tar) construct (PubMed=3022282).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6091; INSR (Note=With p.Asp949_Ser1382del).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P02941; Salmonella typhimurium methyl-accepting chemotaxis protein II (tar) (Note=With p.Met1_Arg170del).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0213 (CHO)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=3022282; DOI=10.1073/pnas.83.21.8137; PMCID=PMC386882
Leland Ellis, David O. Morgan, Daniel Edward Koshland Jr., Eric Clauser, Gregory R. Moe, Gideon Bollag, Richard A. Roth, William J. Rutter;
Linking functional domains of the human insulin receptor with the bacterial aspartate receptor.
Proc. Natl. Acad. Sci. U.S.A. 83:8137-8141(1986)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2