Cellosaurus cell line MGH138 (CVCL

Cellosaurus MGH138 (CVCL_E4DQ)

Entry history
Cell line name	MGH138
Accession	CVCL_E4DQ
Resource Identification Initiative	To cite this cell line use: MGH138 (RRID:CVCL_E4DQ)
Comments	Characteristics: Erlotinib and gefitinib resistant (PubMed=26828195). Omics: Transcriptomics; Microarray. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified (PubMed=26828195). Mutation; HGNC; HGNC:3236; EGFR; Unexplicit; Ex19del; Zygosity=Unspecified (PubMed=26828195).
Disease	Lung non-small cell carcinoma (NCIt: C2926)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=26828195; DOI=10.1038/nm.4040; PMCID=PMC4900892 Aaron Nathaniel Hata, Matthew J. Niederst, Hannah Linn Archibald, Maria Gomez-Caraballo, Faria Madeena Siddiqui, Hillary E. Mulvey, Yosef E. Maruvka, Fei Ji, Hyo-eun Carrie Bhang, Viveksagar Krishnamurthy Radhakrishna, Giulia Siravegna ...Show all 30 authors... , Hai-Chuan Hu, Sana Raoof, Elizabeth L. Lockerman, Anuj Kalsy, Dana Lee, Celina L. Keating, David A. Ruddy, Leah J. Damon, Adam S. Crystal, Carlotta Costa, Zofia Piotrowska, Alberto Bardelli, Anthony John Iafrate, Ruslan I. Sadreyev, Frank Stegmeier, Gad Getz, Lecia VanDam Sequist, Anthony C. Faber, Jeffrey Adam Engelman; Show fewer authors Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition. Nat. Med. 22:262-269(2016)
Entry creation	19-Dec-2024
Last entry update	10-Apr-2025
Version number	2